Wærhaug, Kristine; Mortensen, Rica; Nordhus, Kåre C.; Kuzkov, Vsevolod V.; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-04-08)
Introduction We recently demonstrated that intravenously
infused recombinant human activated protein C (APC)
attenuates ovine lipopolysaccharide (LPS)-induced lung injury.
In this study, our aim was to find out whether treatment with
inhaled aerosolised APC (inhAPC) prevents formation of
increased lung densities and oedema and derangement of
oxygenation during exposure to LPS.
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Methods: ...